Streeterville is a neighborhood in the Near North Side community area of Chicago, Illinois, United States, north of the Chicago River in Cook County. It is bounded by the river on the south, the Magnificent Mile portion of Michigan Avenue on the west, and Lake Michigan on the north and east. Thus, it can be described as the Magnificent Mile plus all land east of it. The majority of the land in this neighborhood is reclaimed landfill and sandbar.

The neighborhood contains a combination of hotels, restaurants, professional office centers, residential high rises, universities, medical facilities, and cultural venues. The area has undergone increased development in the early 21st century as numerous empty lots in Streeterville have been converted into commercial and residential properties, especially in the southern part of the neighborhood.The neighborhood had earlier experienced booms following World War I and World War II.

Streeterville hosts several landmarks and designated places that have been designated as historic districts. The East Lake Shore Drive Historic District, which consists of a row of early 20th century luxury apartments, sits on the northern edge of the district opposite Lake Michigan. The Old Chicago Water Tower District is located along Michigan Avenue where Streeterville meets the border of the River North and Gold Coast (Chicago) neighborhoods at Chicago Avenue. The Water Tower District contains the only public buildings that survived the 1871 Great Chicago Fire. Also, part of the Michigan–Wacker Historic District lies within Streeterville at the southern end of the Magnificent Mile and contains numerous high rises and skyscrapers built in the 1920s.

The neighborhood hosts several individual landmarks. The neighborhood hosts a National Historic Landmark, the Jean Baptiste Point Du Sable Homesite, the home of the first settler in Chicago. Properties in the neighborhood listed in the National Register of Historic Places include 257 East Delaware, the 860-880 Lake Shore Drive Apartments, the Drake Hotel, the Fourth Presbyterian Church of Chicago, the Navy Pier and the Palmolive Building. Other Chicago Landmarks in the neighborhood include Allerton Hotel, Farwell Building, McGraw-Hill Building, Perkins, Fellows & Hamilton Office and Studio, Tribune Tower, and the Woman's Athletic Club.

The neighborhood hosts more than 25 hotels, including the Ritz Carlton, one of three five star hotels in the Midwestern United States, and the historic Drake Hotel. The Peninsula Hotel, another of the three five star hotels in the Midwestern United States, and the Four Seasons Hotel Chicago, the other of the Midwestern five star hotels are located in the neighborhood near Rush Street. These two hotels host the highest rated spas in Illinois.